Publications

2022

Hutter K., T. Rülicke, T.G. Szabo, L. Andersen, A. Villunger and S. Herzog (2022). The miR-15a/16-1 and miR-15b/16-2 clusters regulate early B cell development by limiting IL-7 receptor expression. Front. Immunol. 13:967914. doi: 10.3389/fimmu.2022.967914

Lohmüller M., B.F. Roeck, T.G. Szabo, M.A. Schapfl, F. Pegka, S. Herzog, A. Villunger and F. Schuler (2022). The SKP2-p27 axis defines susceptibility to cell death upon CHK1 inhibition. Mol Oncol. Aug;16(15):2771-2787; doi: 10.1002/1878-0261.13264

Hutter K., S.E. Lindner, C. Kurschat, T. Rülicke, A. Villunger and S. Herzog (2022). The miR-26 family regulates early B cell development and transformation. Life Sci Alliance Apr 22;5(8):e202101303; doi: 10.26508/lsa.202101303

2021

Volland A., M. Lohmüller, E. Heilmann, J. Kimpel, S. Herzog and D. von Laer (2021). Heparan sulfate proteoglycans serve as alternative receptors for low affinity LCMV variants. PLoS Pathog. Oct 14;17(10):e1009996; doi: 10.1371/journal.ppat.1009996

Hutter K., T. Rülicke, M. Drach, L. Andersen, A. Villunger and S. Herzog (2021). Differential roles of miR-15a/16-1 and miR-497/195 clusters in immune cell development and homeostasis. FEBS J. Jul 23; doi: 10.1111/febs.15493.

2020

Hutter K., M. Lohmüller, A. Jukic, F. Eichin, S. Avci, V. Labi, T.G. Szabo, S.M. Hoser, A. Hüttenhofer, A. Villunger and S. Herzog (2020). SAFB2 Enables the Processing of Suboptimal Stem-Loop Structures in Clustered Primary miRNA Transcripts. Mol Cell. Jun 4;78(5):876-889.e6; doi: 10.1016/j.molcel.2020.05.011.

2019

Schoeler K., A. Aufschnaiter, S. Messner, E. Derudder, S. Herzog, A. Villunger, K. Rajewsky and V. Labi (2019). TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells. FEBS J.; doi: 10.1111/febs.14934.

2018

Herzog, S. (2018). Generation of a miRNA sponge library. bio-protocol; doi: 10.21769/BioProtoc.2820

Maschmeyer, P., G. Petkau, F. Siracusa, J. Zimmermann, F. Zügel, A.A. Kühl, K. Lehmann, S. Schimmelpfennig, M. Weber, C. Haftmann, R. Riedel, M. Bardua, G.A. Heinz, C.L. Tran, B.F. Hoyer, F. Hiepe, S. Herzog, J. Wittmann, N. Rajewsky, F.G. Melchers, H.-D. Chang, A. Radbruch and M.-F. Mashreghi (2018). Selective targeting of pro-inflammatory Th1 cells by microRNA-148a-specific antagomirs in vivo. J. Autoimmun.; doi: 10.1016/j.jaut.2017.11.005

2017

Junghans, D. and S. Herzog (2017). Cnn3 regulates neural tube morphogenesis and neuronal stem cell properties. FEBS Journal; doi: 10.1111/febs.14338

Schuler, F., J.G. Weiss, S.E. Lindner, M. Lohmüller, S. Herzog, S.F. Spiegl, P. Menke, S. Geley, V. Labi and A. Villunger (2017).
Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis.

Nat Commun.; doi: 10.1038/s41467-017-01850-4.

Lindner, S.E., M. Lohmüller, B. Kotkamp, F. Schuler, Z. Knust, A. Villunger and S. Herzog (2017). The miR-15 family reinforces the transition from proliferation to differentiation in pre-B cells. EMBO rep.; doi: 10.15252/embr.201643735

2016

Young, A.I., A.M. Law, L. Castillo, S. Chong, H.D. Cullen, M. Koehler, S. Herzog, T. Brummer, E.F. Lee, W.D. Fairlie, M.C. Lucas, D. Herrmann, A. Allam, P. Timpson, D.N. Watkins, E.K. Millar, S.A. O'Toole, D. Gallego-Ortega, C.J. Ormandy and S.R. Oakes (2016). MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib. Breast Cancer Res.; doi: 10.1186/s13058-016-0781-6

Derudder, E., S. Herzog, V. Labi, T. Yasuda, K. Köchert, M. Janz, A. Villunger, M. Schmidt-Supprian and K. Rajewsky (2016). Canonical NF-kB signaling is uniquely required for the long-term persistance of functional mature B cells. Proc Natl Acad Sci U S A; doi: 10.1073/pnas.1604529113

Solchalska, M., E. Ottina, S. Tuzlak, S. Herzog, M. Herold and A. Villunger. (2016). Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival. Cell Death Differ; doi: 10.1038/cdd.2015.130

, , , , , , , , , , , , , , , Activation loop phosphorylation regulates B‐Raf in vivo and transformation by B‐Raf mutants. EMBO (AOP); doi: 10.15252/embj.201592097

2015

Knackmuss, U., S.E. Lindner, T. Aneichyk, B. Kotkamp, Z. Knust, A. Villunger and S. Herzog. (2015). MAP3K11 is a tumor suppressor targeted by the oncomiR miR-125b in early B cells. Cell Death Differ; doi: 10.1038/cdd.2015.87

Flemming, A., Q.Q. Huang, J.P. Jin, H. Jumaa and S. Herzog. (2015). A Conditional Knockout Mouse Model Reveals That Calponin-3 Is Dispensable for Early B Cell Development. PLoS One 5;10(6):e0128385. doi: 10.1371/journal.pone.0128385.

Haug, S., D. Schnerch, S. Halbach, J. Mastroianni, V.I. Dumit, M. Follo, A. Hasenburg, M. Köhler, H. Dierbach, S. Herzog, A. Proske, M. Werner, J. Dengjel, T. Brummer, S. Laßmann, R. Wäsch and R. Zeiser. (2015). Metadherin exon 11 skipping variant enhances metastatic spread of ovarian cancer. Int J Cancer. 15: 2328-40

2013

Lindner, S.E., M. Wissler, A. Gründer, K. Aumann, E. Ottina, L. Peintner, P. Brauns-Schubert, F. Preiss, S. Herzog, C. Borner, C. Charvet, A. Villunger, H.L. Pahl, and U. Maurer. (2013). Increased leukocyte survival and accelerated onset of lymphoma in the absence of MCL-1 S159-phosphorylation. Oncogene doi:10.1038/onc.2013.469

2012

Herzog, S., and H. Jumaa. (2012). Self-recognition and clonal selection: autoreactivity drives the generation of B cells. Curr Opin Immunol. 24: 166-72

Alkhatib, A., M. Werner, E. Hug, S. Herzog, C. Eschbach, H. Faraidun, F. Köhler, T. Wossning, and H. Jumaa. (2012). FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination. J. Exp. Med. 209: 395–406

2011

Hurtz, C., K. Hatzi, L. Cerchietti, M. Braig, E. Park, Y.-M. Kim, S. Herzog, P. Ramezani-Rad, H. Jumaa, M. C. Müller, W.-K. Hofmann, A. Hochhaus, B. H. Ye, A. Agarwal, B. J. Druker, N. P. Shah, A. M. Melnick, and M. Müschen. (2011). BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia. J. Exp. Med. 208: 2163–2174

Duy, C., C. Hurtz, S. Shojaee, L. Cerchietti, H. Geng, S. Swaminathan, L. Klemm, S.-M. Kweon, R. Nahar, M. Braig, E. Park, Y.-M. Kim, W.-K. Hofmann, S. Herzog, H. Jumaa, H. P. Koeffler, J. J. Yu, N. Heisterkamp, T. G. Graeber, H. Wu, B. H. Ye, A. Melnick, and M. Müschen. (2011). BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition. Nature 473: 384–388

2010

Duy, C., J. J. Yu, R. Nahar, S. Swaminathan, S.-M. Kweon, J. M. Polo, E. Valls, L. Klemm, S. Shojaee, L. Cerchietti, W. Schuh, H.-M. Jäck, C. Hurtz, P. Ramezani-Rad, S. Herzog, H. Jumaa, H. P. Koeffler, I. M. de Alborán, A. M. Melnick, B. H. Ye, and M. Müschen. (2010). BCL6 is critical for the development of a diverse primary B cell repertoire. J. Exp. Med. 207: 1209–1221

2009

Trageser, D., I. Iacobucci, R. Nahar, C. Duy, G. von Levetzow, L. Klemm, E. Park, W. Schuh, T. Gruber, S. Herzog, Y.-M. Kim, W.-K. Hofmann, A. Li, C. T. Storlazzi, H.-M. Jäck, J. Groffen, G. Martinelli, N. Heisterkamp, H. Jumaa, and M. Müschen. (2009). Pre-B cell receptor-mediated cell cycle arrest in Philadelphia chromosome-positive acute lymphoblastic leukemia requires IKAROS function. J. Exp. Med. 206: 1739–1753

Herzog, S., M. Reth, and H. Jumaa. (2009). Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signaling. Nat. Rev. Immunol. 9: 195–205

2008

Herzog, S., E. Hug, S. Meixlsperger, J.-H. Paik, R. A. DePinho, M. Reth, and H. Jumaa. (2008). SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway. Nat. Immunol. 9: 623–631

2007

Herzog, S., and H. Jumaa. (2007). The N terminus of the non-T cell activation linker (NTAL) confers inhibitory effects on pre-B cell differentiation. J. Immunol. 178: 2336–2343

2006

Wossning, T., S. Herzog, F. Köhler, S. Meixlsperger, Y. Kulathu, G. Mittler, A. Abe, U. Fuchs, A. Borkhardt, and H. Jumaa. (2006). Deregulated Syk inhibits differentiation and induces growth factor-independent proliferation of pre-B cells. J. Exp. Med. 203: 2829–2840

Brummer, T., P. Martin, S. Herzog, Y. Misawa, R.J. Daly, and M. Reth. (2006). Functional analysis of the regulatory requirements of B-Raf and the B-RafV600E oncoprotein. Oncogene 25:6262–6276

Sprangers, M., N. Feldhahn, S. Herzog, M.-L. Hansmann, M. Reppel, J. Hescheler, H. Jumaa, R. Siebert, and M. Müschen. (2006). The SRC family kinase LYN redirects B cell receptor signaling in human SLP65-deficient B cell lymphoma cells. Oncogene 25:5056–5062

Herzog, S. *), B. Storch*), and H. Jumaa. (2006). Dual role of the adaptor protein SLP-65: organizer of signal transduction and tumor suppressor of pre-B cell leukemia. Immunol. Res. 34:143–155

*) authors contributed equally

2005

Klein, F., N. Feldhahn, S. Herzog, M. Sprangers, J. L. Mooster, H. Jumaa, and M. Müschen. (2005). BCR–ABL1 induces aberrant splicing of IKAROS and lineage infidelity in pre-B lymphoblastic leukemia cells. Oncogene 25: 1118–1124

Feldhahn, N., F. Klein, J.L. Mooster, P. Hadweh, M. Sprangers, M. Wartenberg, M.M. Bekhite, W.-K. Hofmann, S. Herzog, H. Jumaa, J.D. Rowley, and M. Müschen. (2005). Mimicry of a constitutively active pre-B cell receptor in acute lymphoblastic leukemia cells. J. Exp. Med. 201:1837–1852

Köhler, F., B. Storch*), Y. Kulathu*), S. Herzog*), S. Kuppig, M. Reth, and H. Jumaa. (2005). A leucine zipper in the N terminus confers membrane association to SLP-65. Nat. Immunol. 6: 204–210

*) authors contributed equally

2004

Su, Y.-W., S. Herzog, M. Lotz, N. Feldhahn, M. Müschen, and H. Jumaa. (2004). The molecular requirements for LAT-mediated differentiation and the role of LAT in limiting pre-B cell expansion. Eur. J. Immunol. 34: 3614–3622

2002

Moseley, J.L., T. Allinger, S. Herzog, P. Hoerth, E. Wehinger, S. Merchant, and M. Hippler. (2002). Adaptation to Fe-deficiency requires remodeling of the photosynthetic apparatus. EMBO J. 21:6709–6720.

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